Design of enzyme inhibitors using iterative protein crystallographic analysis

J Med Chem. 1991 Jul;34(7):1925-34. doi: 10.1021/jm00111a001.
No abstract available

Publication types

  • Review

MeSH terms

  • Crystallography
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Escherichia coli / drug effects
  • Humans
  • Microbial Sensitivity Tests
  • Stereoisomerism
  • Structure-Activity Relationship
  • Thymidylate Synthase / antagonists & inhibitors

Substances

  • Enzyme Inhibitors
  • Thymidylate Synthase